History, Nation and Politics: the Middle Ages in Modern Portugal (1890-1947)

Nas últimas décadas, o estudo da historiografia, da memória histórica e dos usos do passado tem suscitado cada vez maior atenção junto dos meios académicos. O medievalismo em particular, comummente entendido como a representação ou o uso da Idade Média no período pós-medieval, assume aqui um papel significativo, dada a importância da época medieval na cultura histórica romântica e nos processos de construção das identidades nacionais desde o século XIX. No contexto académico português, porém, o medievalismo foi ainda escassamente analisado, faltando um estudo que abranja as suas várias dimensões, da historiografia às políticas de memória. Esta dissertação pretende colmatar esta lacuna, ao explorar as várias representações da Idade Média em Portugal entre o final do século XIX e a primeira metade do século XX. Focando três grandes temas – escrita da história, património artístico e comemorações históricas – iremos demonstrar como certos conceitos, instituições, figuras, eventos e obras da história medieval portuguesa foram narrados, retrabalhados e celebrados, à luz dos discursos decadentistas sobre a nação e sobre o mundo ocidental e da evolução política do país neste período. Estudos internacionais sobre este tema permitirão a realização de exercícios comparativos, bem como considerar a dimensão transnacional do medievalismo português, inserido nas grandes correntes culturais e ideologias políticas que influenciaram as várias representações da época medieval neste período. No final, iremos verificar como uma visão essencialmente romântica da história portuguesa persistiu ao longo de grande parte do século XX, ao representar dicotomicamente a Idade Média de forma positiva em comparação com uma Modernidade identificada com declínio civilizacional e espiritual.In recent decades, the study of historiography, historical memory and the uses of the past has become a subject of increasing attention in academic circles. Medievalism in particular, commonly understood as the representation or use of the Middle Ages in the post-medieval period, assumes here an significant role, given the importance of the medieval epoch in Romantic historical culture and in nation-building processes since the nineteenth century. However, medievalism has still been scarcely analysed in the Portuguese context, lacking a study that encompasses its multiple dimensions, from historiography to politics of memory. This dissertation aims to fulfil this gap, by exploring the various representations of the Middle Ages in Portugal between the late nineteenth and the first half of the twentieth century. Focusing on three major topics – writing of history, artistic heritage and historical commemorations –, we will demonstrate how certain concepts, institutions, figures, events and works of Portuguese medieval history were narrated, reworked and celebrated, in the light of decadentist discourses about the nation and the Western world and of Portugal‘s political evolution in this period. International research on the topic will allow the making of comparative analyses and the understanding of the transnational dimension of Portuguese medievalism, inserted in the major cultural trends and political ideologies that influenced the various depictions of the medieval epoch in this period. In the end, we will show that an essentially Romantic view of Portuguese history persisted through the twentieth century, dichotomically presenting the Middle Ages in a positive light in comparison with a Modernity identified with civilizational and spiritual decline

Contributos para uma História do Ir à praia em Portugal

Dissertação apresentada para cumprimento dos requisitos necessários à obtenção do grau de Mestre em História ContemporâneaHoje a historiografia reconhece que a prática dos banhos de mar e da ida à praia, com antecedentes na Antiguidade, surgiu no Ocidente em meados do século XVIII. Este é um fenómeno que começa por ter razões de índole estritamente terapêutica, mas que rapidamente se revela como uma prática de amplo significado cultural, envolvendo igualmente dimensões sociais, económicas e políticas. Em Portugal apenas na segunda metade do século XIX a vilegiatura balnear se consolidou do ponto de vista das mentalidades, da organização turística e do enquadramento político. O primeiro objectivo desta tese será traçar uma evolução do ir à praia em Portugal desde os seus primórdios até sensivelmente à década de 70 do século XX, atendendo a factores como o desenvolvimento económico e turístico, a urbanística e a legislação em torno desta prática. Durante a segunda metade do século XIX, algumas daquelas que hoje são praias de renome em Portugal conheceram o seu maior desenvolvimento como estâncias balneares. Procurar-se-á analisar que concepção do ir à praia foi desde este período fomentada pelos grupos sociais da burguesia, os quais estabeleceriam princípios de distinção social perante a generalização desta prática às classes populares. Esta concepção manter-se-ia durante uma boa parte do século XX, pelo menos até ao momento em que, virtude de fenómenos como a massificação do turismo, a expansão do turismo internacional e as novas concepções sobre o corpo, se desenvolveria um modelo de praia diferente do anterior, voltado para as férias, para o sol e para o lazer. É o objectivo desta tese analisar todas estas dinâmicas, situando-as depois num estudo de caso que pretende trazer alguma luz sobre as transformações operadas no turismo balnear em Portugal ao longo do século XX

Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo

Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab

The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Second serological inquiry on migratory birds resident in Lagoa do Peixe National Park for detection of West Nile Fever and other viruses

Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil.Secretaria Municipal de Saúde. Recife, PE, Brasil.Secretaria de Estado de Saúde. Campo Grande, MS, Brasil.Ministério da Agricultura, Pecuária e Abastecimento. Brasília, DF, Brasil.Zoológico de Brasília. Brasília, DF, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade Federal do Rio Grande do Sul - PROAVES. Porto Alegre, RS, Brasil.Secretaria Estadual de Saúde. Porto Alegre, RS, Brasil.Zoológico de Brasília. Brasília, DF, Brasil.Secretaria Estadual de Saúde. Porto Alegre, RS, Brasil.Instituto Brasileiro do Meio Ambiente e dos Recursos Naturais Renováveis. Centro Nacional de Pesquisa para a Conservação das Aves Silvestres. Brasília, DF, Brasil.Ministério da Agricultura, Pecuária e Abastecimento. Brasília, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil

ATLAS OTALEX C

Extremadura, in Spain, and Alentejo and Centro, in Portugal, are tree regions belonging to different countries but with several common interests. They are continuous border areas that share similar ecological, socioeconomic and environmental characteristics. The cooperation between these territories which promotes the collaboration and exchange of information between both sides of the Spanish-Portuguese frontier, has important references in several crossborder projects, such as: COORDSIG “Coordination of Geographical Information Systems and Instruments of Territorial Observation in Low Density Rural Areas”, co-financed by EFRD, program Interreg II C, developed between 1997 and 2001; PLANEXAL “Territorial Recognition for the approach of common urban-territorial management and planning strategies in Extremadura and Alentejo”, co-financed by Interreg III A Spain Portugal Program, between 2003 and 2005; GEOALEX “Geographical model for environmental and territorial management of rural low density areas”, co-financed by Interreg III A (Sub-program Alentejo-Extremadura) from 2004 to 2006; OTALEX “Territorial Observatory Alentejo Extremadura”, co-financed by Interreg III A Spain-Portugal Program, developed from 2006 to 2009; and OTALEX II “Territorial and Environmental Observatory Alentejo Extremadura”, co-financed also by Interreg III A Spain-Portugal Program and developed between 2008 and 2011. Starting in 2009 as the ongoing project of OTALEX II, OTALEX C “Territorial and Environmental Observatory Alentejo Extremadura Centro”, co-financed by the Cross Border Cooperation Operational Program of Spain-Portugal 2007-2013 (POCTEP), has as main purpose the creation of a management and environmental monitoring system thought the SDI – IDE OTALEX (Spatial data infrastructure of the Territorial and Environmental Observatory Alentejo-Extremadura-Centro - www.ideotalex.eu) as an information and institutional sharing platform between Alentejo-Extremadura-Centro administrations. The project is integrated by different spanish and portuguese entities that belong to three levels of administration. At national level the spanish Nacional Centro of Geographical Information / Nacional Geographical Institute (CNIG-IGN) and portuguese General Territory Direction (DGT); at the regional level, the General Direction for Transports, Territorial Management and Urbanism (Consejería of Fomento, Vivienda, Territorial Management and Tourism – Government of Extremadura) and Coordination and Regional Development Commission of Alentejo (CCDR-A); at local level, Intermunicipal Community of Central Alentejo (CIMAC), Intermunicipal Community of Alto Alentejo (CIMAA), O. A. Equality and Local Development Area (Diputación of Badajoz) and Diputación of Cáceres; in the high education, the University of Extremadura, the University of Évora and the Polytechnic Institute of Castelo Branco; and as public enterprise, the Enterprise of Development and Infra-structures of Alqueva Dam, S.A. (EDIA). The publication of this crossborder atlas of Alentejo-Extremadura-Centro regions, the ATLAS OTALEX C, integrates the results of an extensive series of crossborder projects overcoming the fruitful cohesion of territories in the defence of their common interests. The present publication collects and synthetizes the harmonization effort made in bringing in common the information of the distinct partners of OTALEX C project, and aims to contribute in an effective way to the sustainable development of these crossborder regions through the definition of common strategies and of the implementation of crossborder of territorial and environmental observation instruments